Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model

Clonal proliferation of plasma cells within the bone marrow (BM) affects local cells, such as mesenchymal stromal cells (MSCs), leading to osteolysis and fatality in multiple myeloma (MM). Consequently, there is an urgent need to find better mechanisms of inhibiting myeloma growth and osteolytic les...

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Pubblicato in:Blood
Autori principali: Reagan, Michaela R., Mishima, Yuji, Glavey, Siobhan V., Zhang, Yong, Manier, Salomon, Lu, Zhi Ning, Memarzadeh, Masoumeh, Zhang, Yu, Sacco, Antonio, Aljawai, Yosra, Shi, Jiantao, Tai, Yu-Tzu, Ready, John E., Kaplan, David L., Roccaro, Aldo M., Ghobrial, Irene M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239334/
https://ncbi.nlm.nih.gov/pubmed/25205118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-558007
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