CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal transition-like transcriptional activation

Extra-medullary disease (EMD) in Multiple Myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that lead to EMD have not been well defined. We developed bone marrow (BM)- and EMD-prone MM syngeneic cell lines and identified that epithelial-to-...

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Publicado no:Cell Rep
Main Authors: Roccaro, Aldo M., Mishima, Yuji, Sacco, Antonio, Moschetta, Michele, Tai, Yu-Tzu, Shi, Jiantao, Zhang, Yong, Reagan, Michaela R., Huynh, Daisy, Kawano, Yawara, Sahin, Ilyas, Chiarini, Marco, Manier, Salomon, Cea, Michele, Aljawai, Yosra, Glavey, Siobhan, Morgan, Elizabeth, Pan, Chin, Michor, Franziska, Cardarelli, Pina, Kuhne, Michelle, Ghobrial, Irene M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961259/
https://ncbi.nlm.nih.gov/pubmed/26190113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.059
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