CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal transition-like transcriptional activation

Extra-medullary disease (EMD) in Multiple Myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that lead to EMD have not been well defined. We developed bone marrow (BM)- and EMD-prone MM syngeneic cell lines and identified that epithelial-to-...

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Publié dans:Cell Rep
Auteurs principaux: Roccaro, Aldo M., Mishima, Yuji, Sacco, Antonio, Moschetta, Michele, Tai, Yu-Tzu, Shi, Jiantao, Zhang, Yong, Reagan, Michaela R., Huynh, Daisy, Kawano, Yawara, Sahin, Ilyas, Chiarini, Marco, Manier, Salomon, Cea, Michele, Aljawai, Yosra, Glavey, Siobhan, Morgan, Elizabeth, Pan, Chin, Michor, Franziska, Cardarelli, Pina, Kuhne, Michelle, Ghobrial, Irene M.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961259/
https://ncbi.nlm.nih.gov/pubmed/26190113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.059
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