The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma

MYC is a major oncogenic driver of Multiple Myeloma (MM) and yet almost no therapeutic agents exist that target MYC in MM. Here we report that the let-7 biogenesis inhibitor LIN28B correlates with MYC expression in MM and is associated with adverse outcome. We also demonstrate that the LIN28B/let-7...

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Publié dans:Leukemia
Auteurs principaux: Manier, Salomon, Powers, John T., Sacco, Antonio, Glavey, Siobhan V., Huynh, Daisy, Reagan, Michaela R., Salem, Karma Z., Moschetta, Michele, Shi, Jiantao, Mishima, Yuji, Roche-Lestienne, Catherine, Leleu, Xavier, Roccaro, Aldo M., Daley, George Q., Ghobrial, Irene M.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382134/
https://ncbi.nlm.nih.gov/pubmed/27773931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.296
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