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The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma
MYC is a major oncogenic driver of Multiple Myeloma (MM) and yet almost no therapeutic agents exist that target MYC in MM. Here we report that the let-7 biogenesis inhibitor LIN28B correlates with MYC expression in MM and is associated with adverse outcome. We also demonstrate that the LIN28B/let-7...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Leukemia |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5382134/ https://ncbi.nlm.nih.gov/pubmed/27773931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.296 |
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