Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity through effector-mediated functions. We have engineered the fragment crystallizable (Fc) region of the immunoglobulin G (IgG) mAb, HuM195, targeti...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Romain, Gabrielle, Senyukov, Vladimir, Rey-Villamizar, Nicolas, Merouane, Amine, Kelton, William, Liadi, Ivan, Mahendra, Ankit, Charab, Wissam, Georgiou, George, Roysam, Badrinath, Lee, Dean A., Varadarajan, Navin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239333/
https://ncbi.nlm.nih.gov/pubmed/25232058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569061
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