Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity through effector-mediated functions. We have engineered the fragment crystallizable (Fc) region of the immunoglobulin G (IgG) mAb, HuM195, targeti...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Romain, Gabrielle, Senyukov, Vladimir, Rey-Villamizar, Nicolas, Merouane, Amine, Kelton, William, Liadi, Ivan, Mahendra, Ankit, Charab, Wissam, Georgiou, George, Roysam, Badrinath, Lee, Dean A., Varadarajan, Navin
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239333/
https://ncbi.nlm.nih.gov/pubmed/25232058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569061
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