Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity through effector-mediated functions. We have engineered the fragment crystallizable (Fc) region of the immunoglobulin G (IgG) mAb, HuM195, targeti...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Romain, Gabrielle, Senyukov, Vladimir, Rey-Villamizar, Nicolas, Merouane, Amine, Kelton, William, Liadi, Ivan, Mahendra, Ankit, Charab, Wissam, Georgiou, George, Roysam, Badrinath, Lee, Dean A., Varadarajan, Navin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2014
Gaiak:
Immunobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239333/
https://ncbi.nlm.nih.gov/pubmed/25232058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569061
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