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Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells
The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity through effector-mediated functions. We have engineered the fragment crystallizable (Fc) region of the immunoglobulin G (IgG) mAb, HuM195, targeti...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239333/ https://ncbi.nlm.nih.gov/pubmed/25232058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569061 |
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