Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

The Vif protein of HIV-1 allows virus replication by degrading several members of the host-encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host APOBEC3 genes and the viral vif gene have the potential to impact the extent of virus replication among individuals. The most genet...

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Udgivet i:PLoS Genet
Main Authors: Refsland, Eric W., Hultquist, Judd F., Luengas, Elizabeth M., Ikeda, Terumasa, Shaban, Nadine M., Law, Emily K., Brown, William L., Reilly, Cavan, Emerman, Michael, Harris, Reuben S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238949/
https://ncbi.nlm.nih.gov/pubmed/25411794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004761
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