Diminished type I collagen synthesis and reduced alpha 1(I) collagen messenger RNA in cultured fibroblasts from patients with dominantly inherited (type I) osteogenesis imperfecta.

Type I osteogenesis imperfecta (OI) is characterized clinically by a moderate fracture frequency with minimal bone deformity and dominant inheritance. Previous studies of the collagenous proteins synthesized by dermal fibroblasts obtained from unrelated patients with this form of OI suggested that t...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Rowe, D W, Shapiro, J R, Poirier, M, Schlesinger, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423866/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4031065/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112012
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