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Design and specificity of hammerhead ribozymes against calretinin mRNA.
We obtained a partial sequence of mouse calretinin mRNA from cDNA clones, and designed hammerhead ribozymes to cleave positions within it. With a view to optimising hammerhead ribozymes for eliminating the mRNA in vivo, we varied the length and sequence of the three duplex 'arms' and measu...
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| Main Authors: | , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1993
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310633/ https://ncbi.nlm.nih.gov/pubmed/8255773 |
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