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LRRK2 Pathobiology in Parkinson’s Disease
Mutations in the catalytic Roc-COR and kinase domains of leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson’s disease (PD). LRRK2 mutations cause PD with age-related penetrance and clinical features identical to late-onset sporadic PD. Biochemical studies support an increa...
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| Published in: | J Neurochem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4237709/ https://ncbi.nlm.nih.gov/pubmed/25251388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12949 |
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