Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known. Here, we show...

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Main Authors: Martin, Ian, Kim, Jungwoo Wren, Lee, Byoung Dae, Kang, Ho Chul, Xu, Jin-Chong, Jia, Hao, Stankowski, Jeannette, Kim, Min-Sik, Zhong, Jun, Kumar, Manoj, Andrabi, Shaida A., Xiong, Yulan, Dickson, Dennis W., Wszolek, Zbigniew K., Pandey, Akhilesh, Dawson, Ted M., Dawson, Valina L.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040530/
https://ncbi.nlm.nih.gov/pubmed/24725412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.064
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