Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known. Here, we show...

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Autors principals: Martin, Ian, Kim, Jungwoo Wren, Lee, Byoung Dae, Kang, Ho Chul, Xu, Jin-Chong, Jia, Hao, Stankowski, Jeannette, Kim, Min-Sik, Zhong, Jun, Kumar, Manoj, Andrabi, Shaida A., Xiong, Yulan, Dickson, Dennis W., Wszolek, Zbigniew K., Pandey, Akhilesh, Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040530/
https://ncbi.nlm.nih.gov/pubmed/24725412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.064
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