Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes

LRRK2 mutations are a frequent cause of familial Parkinson disease (PD) and are also found in a number of sporadic PD cases. PD-linked G2019S and I2020T mutations in the kinase domain of LRRK2 result in elevated kinase activity, which is required for the toxicity of these pathogenic variants in cell...

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Vydáno v:Fly (Austin)
Hlavní autoři: Martin, Ian, Abalde-Atristain, Leire, Kim, Jungwoo Wren, Dawson, Ted M, Dawson, Valina L
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594515/
https://ncbi.nlm.nih.gov/pubmed/25483009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336934.2014.983382
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