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Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes
LRRK2 mutations are a frequent cause of familial Parkinson disease (PD) and are also found in a number of sporadic PD cases. PD-linked G2019S and I2020T mutations in the kinase domain of LRRK2 result in elevated kinase activity, which is required for the toxicity of these pathogenic variants in cell...
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| Publicado no: | Fly (Austin) |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594515/ https://ncbi.nlm.nih.gov/pubmed/25483009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336934.2014.983382 |
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