Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known. Here, we show...

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Bibliografische gegevens
Hoofdauteurs: Martin, Ian, Kim, Jungwoo Wren, Lee, Byoung Dae, Kang, Ho Chul, Xu, Jin-Chong, Jia, Hao, Stankowski, Jeannette, Kim, Min-Sik, Zhong, Jun, Kumar, Manoj, Andrabi, Shaida A., Xiong, Yulan, Dickson, Dennis W., Wszolek, Zbigniew K., Pandey, Akhilesh, Dawson, Ted M., Dawson, Valina L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040530/
https://ncbi.nlm.nih.gov/pubmed/24725412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.064
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