Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity

AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy. Recent work has found that amyloidogenic LC directly initiate a cardio-toxic response underlying the pathogenes...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Main Authors: Guan, Jian, Mishra, Shikha, Qiu, Yiling, Shi, Jianru, Trudeau, Kyle, Las, Guy, Liesa, Marc, Shirihai, Orian S, Connors, Lawreen H, Seldin, David C, Falk, Rodney H, MacRae, Calum A, Liao, Ronglih
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237473/
https://ncbi.nlm.nih.gov/pubmed/25319546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404190
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