Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38α MAPK pathway

Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The mol...

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Bibliografische gegevens
Hoofdauteurs: Shi, Jianru, Guan, Jian, Jiang, Bingbing, Brenner, Daniel A., del Monte, Federica, Ward, Jennifer E., Connors, Lawreen H., Sawyer, Douglas B., Semigran, Marc J., Macgillivray, Thomas E., Seldin, David C., Falk, Rodney, Liao, Ronglih
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840082/
https://ncbi.nlm.nih.gov/pubmed/20150510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912263107
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