Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and fatal cardiomyopathy resulting from the direct cardiotoxic effects of circulating AL light chain (AL-LC) proteins and the indirect effects of AL fibril tissue infiltration. Cardiac amyloidosis is resistant to st...

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Main Authors: Mishra, Shikha, Guan, Jian, Plovie, Eva, Seldin, David C., Connors, Lawreen H., Merlini, Giampaolo, Falk, Rodney H., MacRae, Calum A., Liao, Ronglih
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Integrative Cardiovascular Physiology and Pathophysiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727100/
https://ncbi.nlm.nih.gov/pubmed/23624626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00186.2013
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