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Homocysteine Induces Cardiomyocyte Dysfunction and Apoptosis through p38 MAPK-Mediated Increase in Oxidant Stress

Elevated plasma homocysteine (Hcy) is a risk factor for cardiovascular disease. While Hcy has been shown to promote endothelial dysfunction by decreasing the bioavailability of nitric oxide and increasing oxidative stress in the vasculature, the effects of Hcy on cardiomyocytes remain less understoo...

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Hlavní autoři: Wang, Xu, Cui, Lei, Joseph, Jacob, Jiang, Bingbing, Pimental, David, Handy, Diane E., Liao, Ronglih, Loscalzo, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294144/
https://ncbi.nlm.nih.gov/pubmed/22227328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.12.009
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