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Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity
In pancreatic β-cells, liver hepatocytes, and cardiomyocytes, chronic exposure to high levels of fatty acids (lipotoxicity) inhibits autophagic flux and concomitantly decreases lysosomal acidity. Whether impaired lysosomal acidification is causally inhibiting autophagic flux and cellular functions c...
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| Pubblicato in: | J Cell Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4932370/ https://ncbi.nlm.nih.gov/pubmed/27377248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201511042 |
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