Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence

Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify putative direct Notch targets in the aorta-gonad-mesonephros (AGM) embryonic...

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Publicado en:J Exp Med
Main Authors: Guiu, Jordi, Bergen, Dylan J.M., De Pater, Emma, Islam, Abul B.M.M.K., Ayllón, Verónica, Gama-Norton, Leonor, Ruiz-Herguido, Cristina, González, Jessica, López-Bigas, Nuria, Menendez, Pablo, Dzierzak, Elaine, Espinosa, Lluis, Bigas, Anna
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235648/
https://ncbi.nlm.nih.gov/pubmed/25385755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131857
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