Allosteric induction of the CD4-bound conformation of HIV-1 Gp120

BACKGROUND: HIV-1 infection of target cells is mediated via the binding of the viral envelope protein, gp120, to the cell surface receptor CD4. This interaction leads to conformational rearrangements in gp120 forming or revealing CD4 induced (CD4i) epitopes which are critical for the subsequent reco...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Retrovirology
Main Authors: Roitburd-Berman, Anna, Dela, Gal, Kaplan, Gilad, Lewis, George K, Gershoni, Jonathan M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235218/
https://ncbi.nlm.nih.gov/pubmed/24304511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-147
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