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The general mode of translation inhibition by macrolide antibiotics

Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially a...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kannan, Krishna, Kanabar, Pinal, Schryer, David, Florin, Tanja, Oh, Eugene, Bahroos, Neil, Tenson, Tanel, Weissman, Jonathan S., Mankin, Alexander S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234590/
https://ncbi.nlm.nih.gov/pubmed/25349425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417334111
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