Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or from up-regulation of compensatory signa...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R., Rusan, Maria, Zhu, Su-Jie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G., Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo, Sim, Taebo, Gaudet, Suzanne, Barbie, David A., Yeh, Jing-Ruey Joanna, Yun, Cai-Hong, Hammerman, Peter S., Mohammadi, Moosa, Jänne, Pasi A., Gray, Nathanael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234547/
https://ncbi.nlm.nih.gov/pubmed/25349422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403438111
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