Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or from up-regulation of compensatory signa...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R., Rusan, Maria, Zhu, Su-Jie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G., Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo, Sim, Taebo, Gaudet, Suzanne, Barbie, David A., Yeh, Jing-Ruey Joanna, Yun, Cai-Hong, Hammerman, Peter S., Mohammadi, Moosa, Jänne, Pasi A., Gray, Nathanael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234547/
https://ncbi.nlm.nih.gov/pubmed/25349422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403438111
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