Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7-bidentate adduct on adjacent deoxyguanosines. A novel immunoassay was used to quantitate this adduct in buffy co...

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Библиографические подробности
Главные авторы: Reed, E, Yuspa, S H, Zwelling, L A, Ozols, R F, Poirier, M C
Формат: Artigo
Язык:Inglês
Опубликовано: 1986
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC423377/
https://ncbi.nlm.nih.gov/pubmed/3944268
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