Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7-bidentate adduct on adjacent deoxyguanosines. A novel immunoassay was used to quantitate this adduct in buffy co...

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Опубликовано в: :J Clin Invest
Главные авторы: Reed, E, Yuspa, S H, Zwelling, L A, Ozols, R F, Poirier, M C
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1986
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423377/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3944268/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112335
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