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Detection of platinum-DNA adducts by 32P-postlabelling.

We developed a sensitive 32P-postlabeling method for the detection of bifunctional intrastrand crosslinks d(Pt-GpG) and d(Pt-ApG) in DNA in vitro and in vivo. After enzymatic digestion of DNA the positively charged platinum adducts were purified from unplatinated products, using strong cation exchan...

Deskribapen osoa

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Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Blommaert, F A, Saris, C P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 1995
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306853/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753620/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.8.1300
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