Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7-bidentate adduct on adjacent deoxyguanosines. A novel immunoassay was used to quantitate this adduct in buffy co...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Reed, E, Yuspa, S H, Zwelling, L A, Ozols, R F, Poirier, M C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1986
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3944268/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112335
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