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GPER-targeted, (99m)Tc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding

Our understanding of estrogen (E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein-coupled estrogen receptor (GPER1/GPER/GPR30) and the development of GPER-selective functional chemical probes. GPER is highly expressed in c...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Nayak, Tapan K., Ramesh, Chinnasamy, Hathaway, Helen J., Norenberg, Jeffrey P., Arterburn, Jeffrey B., Prossnitz, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233156/
https://ncbi.nlm.nih.gov/pubmed/25030373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0289
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