PTEN deficiency mediates a reciprocal response to IGF-1 and mTOR inhibition

Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing Sarcoma, a highly malignant bone and soft tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studies of therapies that target this pathway, early pha...

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Pubblicato in:Mol Cancer Res
Autori principali: Patel, Mukund, Gomez, Nicholas C., McFadden, Andrew W., Moats-Staats, Billie M., Wu, Sam, Rojas, Andres, Sapp, Travis, Simon, Jeremy M., Smith, Scott V., Kaiser-Rogers, Kathleen, Davis, Ian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233155/
https://ncbi.nlm.nih.gov/pubmed/24994750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0006
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