IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

PURPOSE: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (si...

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發表在:Endocrine
Main Authors: De Martino, Maria Cristina, van Koetsveld, Peter M., Feelders, Richard A., de Herder, Wouter W., Dogan, Fadime, Janssen, Joseph A. M. J. L., Hofste op Bruinink, Davine, Pivonello, Claudia, Waaijers, A. Marlijn, Colao, Annamaria, de Krijger, Ronald R., Pivonello, Rosario, Hofland, Leo J.
格式: Artigo
語言:Inglês
出版: Springer US 2019
主題:
Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551351/
https://ncbi.nlm.nih.gov/pubmed/30838516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-019-01869-1
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