IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

PURPOSE: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (si...

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Detalhes bibliográficos
Publicado no:Endocrine
Principais autores: De Martino, Maria Cristina, van Koetsveld, Peter M., Feelders, Richard A., de Herder, Wouter W., Dogan, Fadime, Janssen, Joseph A. M. J. L., Hofste op Bruinink, Davine, Pivonello, Claudia, Waaijers, A. Marlijn, Colao, Annamaria, de Krijger, Ronald R., Pivonello, Rosario, Hofland, Leo J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551351/
https://ncbi.nlm.nih.gov/pubmed/30838516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-019-01869-1
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