IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

PURPOSE: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (si...

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Bibliografske podrobnosti
izdano v:Endocrine
Main Authors: De Martino, Maria Cristina, van Koetsveld, Peter M., Feelders, Richard A., de Herder, Wouter W., Dogan, Fadime, Janssen, Joseph A. M. J. L., Hofste op Bruinink, Davine, Pivonello, Claudia, Waaijers, A. Marlijn, Colao, Annamaria, de Krijger, Ronald R., Pivonello, Rosario, Hofland, Leo J.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2019
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551351/
https://ncbi.nlm.nih.gov/pubmed/30838516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-019-01869-1
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