IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

PURPOSE: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (si...

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Publicat a:Endocrine
Autors principals: De Martino, Maria Cristina, van Koetsveld, Peter M., Feelders, Richard A., de Herder, Wouter W., Dogan, Fadime, Janssen, Joseph A. M. J. L., Hofste op Bruinink, Davine, Pivonello, Claudia, Waaijers, A. Marlijn, Colao, Annamaria, de Krijger, Ronald R., Pivonello, Rosario, Hofland, Leo J.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2019
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551351/
https://ncbi.nlm.nih.gov/pubmed/30838516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12020-019-01869-1
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