Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

Overexpression of transforming growth factor β (TGF-β) has been shown to play pathogenic roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlates better with renal function than the severity of glomerulosclerosis. Smad proteins are signaling transducers down...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Fukasawa, Hirotaka, Yamamoto, Tatsuo, Togawa, Akashi, Ohashi, Naro, Fujigaki, Yoshihide, Oda, Toshiaki, Uchida, Chiharu, Kitagawa, Kyoko, Hattori, Takayuki, Suzuki, Sayuri, Kitagawa, Masatoshi, Hishida, Akira
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423256/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15173588/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400035101
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