Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

Overexpression of transforming growth factor β (TGF-β) has been shown to play pathogenic roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlates better with renal function than the severity of glomerulosclerosis. Smad proteins are signaling transducers down...

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Autors principals: Fukasawa, Hirotaka, Yamamoto, Tatsuo, Togawa, Akashi, Ohashi, Naro, Fujigaki, Yoshihide, Oda, Toshiaki, Uchida, Chiharu, Kitagawa, Kyoko, Hattori, Takayuki, Suzuki, Sayuri, Kitagawa, Masatoshi, Hishida, Akira
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC423256/
https://ncbi.nlm.nih.gov/pubmed/15173588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400035101
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