Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

Overexpression of transforming growth factor β (TGF-β) has been shown to play pathogenic roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlates better with renal function than the severity of glomerulosclerosis. Smad proteins are signaling transducers down...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Fukasawa, Hirotaka, Yamamoto, Tatsuo, Togawa, Akashi, Ohashi, Naro, Fujigaki, Yoshihide, Oda, Toshiaki, Uchida, Chiharu, Kitagawa, Kyoko, Hattori, Takayuki, Suzuki, Sayuri, Kitagawa, Masatoshi, Hishida, Akira
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423256/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15173588/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400035101
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