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Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53
The CRISPR (clustered regularly interspaced short palindromic repeats) platform has been developed as a general method to direct proteins of interest to gene targets. While the native CRISPR system delivers a nuclease that cleaves and potentially mutates target genes, researchers have recently emplo...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232525/ https://ncbi.nlm.nih.gov/pubmed/25398078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113232 |
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