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Covalent Docking of Large Libraries for the Discovery of Chemical Probes
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency, and utility for biological studies. Despite these advantages, protein-reactive compounds are usually avoided in high-throughput screening campaigns. Here we describe a general method (DOCKovalen...
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| Publié dans: | Nat Chem Biol |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232467/ https://ncbi.nlm.nih.gov/pubmed/25344815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1666 |
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