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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5′-end of mRNAs, stimulating the translation of proteins implicated in cancer cell growth and metastasis. eIF4E is a notoriously challenging target, and most of the reported inhibitors are negatively charged gua...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7136196/ https://ncbi.nlm.nih.gov/pubmed/32105459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b10377 |
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