Hsp70 promotes TNF-mediated apoptosis by binding IKKγ and impairing NF-κB survival signaling

The major heat shock protein, Hsp70, can protect against cell death by directly interfering with mitochondrial apoptosis pathways. However, Hsp70 also sensitizes cells to certain apoptotic stimuli like TNF. Little is known about how Hsp70 enhances apoptosis. We demonstrate here that Hsp70 promotes T...

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Autores principales: Ran, Ruiqiong, Lu, Aigang, Zhang, Lu, Tang, Yang, Zhu, Hongyan, Xu, Huichun, Feng, Yuxin, Han, Chun, Zhou, Guoping, Rigby, Alan C., Sharp, Frank R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC423196/
https://ncbi.nlm.nih.gov/pubmed/15198984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1188204
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