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Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival
Although wild-type Hsp70 (Hsp70WT) inhibits procaspase-3 processing by preventing apoptosome formation, Hsp70WT does not block active caspase-3. Because all caspase-3 inhibitors bear canonical DXXD caspase-3 recognition motifs, we determined whether mutated Hsp70s with caspase-binding motifs act as...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Stress Society International
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1065282/ https://ncbi.nlm.nih.gov/pubmed/15544161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1379/CSC-19R.1 |
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