Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival

Although wild-type Hsp70 (Hsp70WT) inhibits procaspase-3 processing by preventing apoptosome formation, Hsp70WT does not block active caspase-3. Because all caspase-3 inhibitors bear canonical DXXD caspase-3 recognition motifs, we determined whether mutated Hsp70s with caspase-binding motifs act as...

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Detalhes bibliográficos
Main Authors: Ran, Ruiqiong, Zhou, Guoping, Lu, Aigang, Zhang, Lu, Tang, Yang, Rigby, Alan C., Sharp, Frank R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Stress Society International 2004
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065282/
https://ncbi.nlm.nih.gov/pubmed/15544161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1379/CSC-19R.1
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