Hsp70 promotes TNF-mediated apoptosis by binding IKKγ and impairing NF-κB survival signaling

The major heat shock protein, Hsp70, can protect against cell death by directly interfering with mitochondrial apoptosis pathways. However, Hsp70 also sensitizes cells to certain apoptotic stimuli like TNF. Little is known about how Hsp70 enhances apoptosis. We demonstrate here that Hsp70 promotes T...

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Detalhes bibliográficos
Main Authors: Ran, Ruiqiong, Lu, Aigang, Zhang, Lu, Tang, Yang, Zhu, Hongyan, Xu, Huichun, Feng, Yuxin, Han, Chun, Zhou, Guoping, Rigby, Alan C., Sharp, Frank R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC423196/
https://ncbi.nlm.nih.gov/pubmed/15198984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1188204
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