Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

The lack of the neuropeptide orexin, also known as hypocretin, results in narcolepsy, a chronic sleep disorder characterized by frequent sleep/cataplexy attacks and rapid eye movement sleep abnormalities. However, the downstream pathways of orexin signaling are not clearly understood. Here, we show...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Wang, Zhiqiang, Liu, Shimeng, Kakizaki, Miyo, Hirose, Yuuki, Ishikawa, Yukiko, Funato, Hiromasa, Yanagisawa, Masashi, Yu, Yonghao, Liu, Qinghua
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231673/
https://ncbi.nlm.nih.gov/pubmed/25278019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600015
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