Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

The lack of the neuropeptide orexin, also known as hypocretin, results in narcolepsy, a chronic sleep disorder characterized by frequent sleep/cataplexy attacks and rapid eye movement sleep abnormalities. However, the downstream pathways of orexin signaling are not clearly understood. Here, we show...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Wang, Zhiqiang, Liu, Shimeng, Kakizaki, Miyo, Hirose, Yuuki, Ishikawa, Yukiko, Funato, Hiromasa, Yanagisawa, Masashi, Yu, Yonghao, Liu, Qinghua
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231673/
https://ncbi.nlm.nih.gov/pubmed/25278019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600015
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