Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells

Over the years, Chinese hamster ovary (CHO) cells have emerged as the major host for expressing biotherapeutic proteins. Traditional methods to generate high-producer cell lines rely on random integration(s) of the gene of interest but have thereby left the identification of bottlenecks as a challen...

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Dettagli Bibliografici
Pubblicato in:Appl Microbiol Biotechnol
Autori principali: Mayrhofer, Patrick, Kratzer, Bernhard, Sommeregger, Wolfgang, Steinfellner, Willibald, Reinhart, David, Mader, Alexander, Turan, Soeren, Qiao, Junhua, Bode, Juergen, Kunert, Renate
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2014
Soggetti:
Applied Genetics and Molecular Biotechnology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231286/
https://ncbi.nlm.nih.gov/pubmed/25158835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-014-6011-1
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