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Identification of transgene integration loci of different highly expressing recombinant CHO cell lines by FISH
Recombinant CHO cell lines have integrated the expression vectors in various parts of the genome leading to different levels of gene amplification, productivity and stability of protein expression. Identification of insertion sites where gene amplification is possible and the transcription rate is h...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic Publishers
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449811/ https://ncbi.nlm.nih.gov/pubmed/19002887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-006-9029-0 |
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