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Identification of transgene integration loci of different highly expressing recombinant CHO cell lines by FISH

Recombinant CHO cell lines have integrated the expression vectors in various parts of the genome leading to different levels of gene amplification, productivity and stability of protein expression. Identification of insertion sites where gene amplification is possible and the transcription rate is h...

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Detalhes bibliográficos
Main Authors: Lattenmayer, Christine, Loeschel, Martina, Steinfellner, Willibald, Trummer, Evelyn, Mueller, Dethardt, Schriebl, Kornelia, Vorauer-Uhl, Karola, Katinger, Hermann, Kunert, Renate
Formato: Artigo
Idioma:Inglês
Publicado em: Kluwer Academic Publishers 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449811/
https://ncbi.nlm.nih.gov/pubmed/19002887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-006-9029-0
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