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Effective sample size for computing prior hyperarameters in Bayesian phase I-II dose-finding

BACKGROUND: The efficacy-toxicity trade-off based design is a practical Bayesian phase I-II dose-finding methodology. Because the design's performance is very sensitive to prior hyperparameters and the shape of the target trade-off contour, specifying these two design elements properly is essen...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Thall, Peter F., Herrick, Richard C., Nguyen, Hoang Q., Venier, John J., Norris, J. Clift
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229398/
https://ncbi.nlm.nih.gov/pubmed/25179541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774514547397
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