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Adaptive Randomization to Improve Utility-Based Dose-Finding with Bivariate Ordinal Outcomes
A sequentially outcome-adaptive Bayesian design is proposed for choosing the dose of an experimental therapy based on elicited utilities of a bivariate ordinal (toxicity, efficacy) outcome. Subject to posterior acceptability criteria to control the risk of severe toxicity and exclude unpromising dos...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3385658/ https://ncbi.nlm.nih.gov/pubmed/22651115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2012.676586 |
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