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Parametric Dose Standardization for Optimizing Two-Agent Combinations in a Phase I–II Trial with Ordinal Outcomes
A Bayesian model and design are described for a phase I-II trial to jointly optimise the doses of a targeted agent and a chemotherapy agent for solid tumors. A challenge in designing the trial was that both the efficacy and toxicity outcomes were defined as four-level ordinal variables. To reflect p...
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| Publicado no: | J R Stat Soc Ser C Appl Stat |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5328131/ https://ncbi.nlm.nih.gov/pubmed/28255183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12162 |
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