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Parametric Dose Standardization for Optimizing Two-Agent Combinations in a Phase I–II Trial with Ordinal Outcomes

A Bayesian model and design are described for a phase I-II trial to jointly optimise the doses of a targeted agent and a chemotherapy agent for solid tumors. A challenge in designing the trial was that both the efficacy and toxicity outcomes were defined as four-level ordinal variables. To reflect p...

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Detalhes bibliográficos
Publicado no:J R Stat Soc Ser C Appl Stat
Main Authors: Thall, Peter F., Nguyen, Hoang Q., Zinner, Ralph G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328131/
https://ncbi.nlm.nih.gov/pubmed/28255183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12162
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