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A decision-theoretic phase I–II design for ordinal outcomes in two cycles
This paper is motivated by a phase I–II clinical trial of a targeted agent for advanced solid tumors. We study a stylized version of this trial with the goal to determine optimal actions in each of two cycles of therapy. A design is presented that generalizes the decision-theoretic two-cycle design...
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| Published in: | Biostatistics |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4834949/ https://ncbi.nlm.nih.gov/pubmed/26553915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv045 |
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