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Bayesian decision theoretic two-stage design in Phase II clinical trials with survival endpoint
In this paper, we consider two-stage designs with failure-time endpoints in single arm phase II trials. We propose designs in which stopping rules are constructed by comparing the Bayes risk of stopping at stage one to the expected Bayes risk of continuing to stage two using both the observed data i...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167619/ https://ncbi.nlm.nih.gov/pubmed/22359354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4511 |
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